英國科學傢找到瞭炎癥性腸病（IBD）的一個主要病因。科學傢們在我們的 DNA 中發現瞭一個薄弱點，95% 的患者的 DNA 中都存在這個弱點。
Crohn’s disease and ulcerative colitis are the most common forms of inflammatory bowel disease. One part of the immune system, called macrophages, is highly implicated.
克羅恩病和潰瘍性結腸炎是最常見的炎癥性腸病。人體免疫系統中巨噬細胞與病因密切相關。
The researchers at the Francis Crick Institute discovered the macrophages master regulator of inflammation is a section of DNA that controls the whole suite of inflammatory chemicals that the cells release, and some people are born with a version that makes their body respond excessively.
弗朗西斯·克裡克研究所的研究人員發現，巨噬細胞作為炎癥的主調節器，也是一段脫氧核糖核酸（DNA），該段 DNA 控制著細胞釋放的一整套炎癥化學物質，而有些人天生就有一種不同的 DNA “版本”，會讓身體反應過度。
The researchers use this knowledge to test drugs that are already approved for other conditions. These could calm inflammation in samples of bowel tissue from IBD patients.
研究人員利用這些知識來測試已獲批用於治療其它疾病的藥物。這些藥物應該可以緩解在炎癥性腸病患者腸道組織樣本中已發現的炎癥。
詞匯表
ulcerative colitis 潰瘍性結腸炎
inflammatory bowel disease 炎癥性腸病
immune system 免疫系統
macrophages 巨噬細胞
implicated 密切相關的，有關聯的
regulator 調節器，管理者
DNA 脫氧核糖核酸
suite 一套、一整套
inflammatory 引起炎癥的，發炎的
excessively 過度的
tissue （細胞）組織
IBD 炎癥性腸病
閱讀理解：請在讀完上文後，回答下列問題。
1. What part of the body is responsible for inflammatory bowel disease?
2. What part of the body controls the inflammatory chemicals released by cells?
3. True or False? Some people are born with a section of DNA that makes their bodies produce more inflammatory chemicals than they need.
4. True or False? Doctors are treating IBD with drugs made for other illnesses.
答案
1. What part of the body is responsible for inflammatory bowel disease?
One part of the immune system, called macrophages, is highly implicated.
2. What part of the body controls the inflammatory chemicals released by cells?
The macrophages master regulator of information is a section of DNA that controls the whole suite of inflammatory chemicals.
3. True or False? Some people are born with a section of DNA that makes their bodies produce more inflammatory chemicals than they need.
True. Some people are born with a version that makes their bodies respond excessively.
4. True or False? Doctors are treating IBD with drugs made for other illnesses.
False. Researchers are testing drugs that are already approved for other conditions.
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